Rare germline variants such as MER proto-oncogene, tyrosine kinase (MERTK) [57]; MET proto-oncogene, receptor tyrosine kinase (MET, germline and somatic) [57], and somatic alterations such as KIF1B (germline and somatic) [109], Harvey rat sarcoma viral oncoprotein (HRAS) [110], B-rapidly accelerated fibrosarcoma (BRAF) [110], nerve growth factor receptor (NGFR) [72], and fibroblast growth factor receptor 1 (FGFR1) have recently been added to this pathway [24, 57, 72, 111]. This evidence concerns the gene HRAS and fibrosarcoma.