HLA-C and infection: We propose that simultaneous upregulation of HLA-C, -G, and -F on viral reservoir cells during early-treated infection represents a consequence of innate immune selection that promotes preferential persistence of target cells with higher levels of resistance to cytolytic NK cells and, possibly, other innate immune cells; future studies designed to assess HLA class I expression on target cells in conjunction with their corresponding activating and inhibitory ligands on innate immune effector cells may help to further explore this hypothesis.