Compared with normal serum CEA levels, elevated serum CEA levels were associated with a 529% increased risk of peritoneal metastasis (HR ═ 6.29, 95% CI ═ 5.41–7.35; P < 0.001), a 419% increase in distant lymphatic metastasis (HR ═ 5.19, 95% CI ═ 4.45–6.08; P < 0.001) and even a 751% increase in liver metastasis (HR ═ 8.51, 95% CI ═ 7.71–9.41; P < 0.001). This evidence concerns the gene CEACAM5 and Lymphatic Metastasis.