HEATR1 and familial pancreatic carcinoma: For example, in oral squamous cell carcinoma (OSCC), HEATR1 acts as a binding factor for the Pontin/Reptin complex, which is overexpressed in tumor cells (Nakamura et al., 2021), while in pancreatic cancer HEATR1 inhibits the activity of the Nrf2 factor that participates in the protection of cells from oxidative stress (Zhou et al., 2020).