Patients with HFpEF exhibited significantly higher proportions of females, more hypertension, atrial fibrillation, NT‐proBNP elevation, older age, and increased use of antihypertensive medications and diuretics, alongside decreased hemoglobin levels (p < 0.05) compared to non‐HFpEF individuals. The gene discussed is NPPB; the disease is hypertensive disorder.