They play crucial roles in suppressing tumor invasion and metastasis in HPV-negative SCC.[45,46] LncRNA PTCSC3 and lncRNA GAS5 exert tumor-suppressive effects by inducing cell apoptosis.[47,48] LncRNA 00887 exerts its tumor-suppressive effects by inhibiting cell proliferation and invasion through the suppression of the miR-454-3p-mediated FRMD6-Hippo signaling pathway. This evidence concerns the gene FRMD6 and neoplasm.