Therefore, interventions targeting the HIF-1α pathway are a hot research topic in cancer treatment.[39] Research has found that lncRNA ANCR inhibits tumor cell growth in HPV-negative SCC under hypoxic conditions by suppressing HIF-1α.[32] In HPV-negative patients, cervical tissues and serum show significantly decreased or completely lost expression of lncRNA ANCR compared to normal females and HPV-positive SCC patients. The gene discussed is HIF1A; the disease is cancer.