Multiple studies have demonstrated that lncRNA HAND2-AS1 inhibits tumor cell growth, invasion, and metastasis in SCC.[41–43] Researchers have found that lncRNA HAND2-AS1 not only regulates the VEGFA signaling pathway but also competitively binds to miR-21-5p to downregulate the expression of TIMP3, resisting cell apoptosis. Here, HAND2 is linked to neoplasm.