PIK3CA and adenocarcinoma: Recently, Jenkins et al conducted genetic testing on 8 HPV-negative patients with endocervical-like adenocarcinoma and found mutations in various somatic genes, including PIK3CA (50%), PTEN (50%), CTNNB1 (37.5%), FBXW7 (25%), KRAS (12.5%), AKT1 (12.5%), and MSI-H (12.5%).