IGHE and Alzheimer disease: The activity of Th2 cells is notably increased, producing cytokines such as IL-4, IL-5, and IL-13, which promote IgE production by B cells and recruit and activate eosinophils, leading to allergic reactions and skin inflammation.[6–8] Dendritic cells (DC) also play a crucial role in AD by capturing and processing antigens and modulating immune responses through interactions with T cells.[3,9] Monocytes and macrophages contribute to AD by producing pro-inflammatory cytokines and chemokines, resulting in inflammation and tissue damage.