Our previous study has demonstrated that IL-8 promotes integrin β3 upregulation and the invasion of HCC cells through PI3K/Akt pathway.[22] In this study, we found a positive relationship between IL-8 and integrin β3 expression in HCC, and patients with positive IL-8 and integrin β3 expression had a significantly shorter overall survival time. This evidence concerns the gene AKT1 and hepatocellular carcinoma.