Increasing evidence suggests that the close relationship between IL-8 and integrin β3 is critical for cancer progression.[25,26] Our previous study has demonstrated that IL-8 promotes integrin β3 upregulation and cell invasion through PI3K/Akt pathway in HCC.[22] However, the value of IL-8 and integrin β3 in prognosis prediction and targeted therapy of HCC remains unclear. This evidence concerns the gene CXCL8 and hepatocellular carcinoma.