Prostate cancer is 1 of the most common malignancies affecting the male genitourinary system, ranking second and fourth in terms of incidence and mortality among male malignancies worldwide, respectively.[1] Basic research has confirmed that GLP-1R can be expressed in human prostate cancer tissues, and This article aims to review the potential role of GLP-1RAs in prostate cancer and explore the underlying mechanisms involved. This evidence concerns the gene GLP1R and Familial prostate cancer.