Immunoprofile: carcinoembryonic antigen (CEA) and creatine kinase (CK) CK7 positive; p40, Napsin A, and TTF-1 negative; c-MET weakly positive (1+); ALK-negative; p53 expressed in 30% of tumor cells; Ki-67 proliferation index at 60%; SMARCA4 absent, indicating loss; CD56 negative (Fig. 2). The gene discussed is CEACAM5; the disease is neoplasm.