The gene SMARCA4 on chromosome 19q13 encodes the BRG1 protein, a component of the SWI/SNF chromatin remodeling complex, pivotal in tumorigenesis and progression.[1] Representing about 8% to 11% of lung cancers, SMARCA4-deficient NSCLC exhibits high malignancy, aggressive behavior, and poor prognosis, generally demonstrating suboptimal responses to cytotoxic chemotherapy.[2] Rarely do these NSCLCs harbor common oncogenic driver mutations such as EGFR, ALK, and ROS1, and no standardized treatment protocols exist for this subtype. This evidence concerns the gene EGFR and lung cancer.