On the other hand, the presence of adrenal incidentalomas, along with the level of ACTH (<0.05, reference range 9–52 pg/mL) and cortisol (16.3 after overnight dexamethasone suppression test, reference range 5–25 μg/dL) confirmed an ACTH-independent mild CS coupled with MDD and GAD. The gene discussed is POMC; the disease is adrenal cortex adenoma.