High-intensity interval training (HIIT) leads to more pronounced increases in BDNF compared to steady-state aerobic activities, suggesting that tailored exercise interventions could optimize neuroplastic benefits and support anxiety management.[12,25] These neuroplastic changes have been associated with significant improvements in mood, cognitive function, and resilience to stress, indicating that the relationship between aerobic exercise and anxiety is underpinned by both biochemical and structural brain changes.[22]. The gene discussed is BDNF; the disease is Anxiety.