DHRS3 and hepatocellular carcinoma: ADH4 was associated with diseases like Parkinson and exhibits dysregulated expression in various tumors, such as lung cancer and hepatocellular carcinoma.[27–29] As a member of the short-chain dehydrogenase/reductase (SDR) family, DHRS3 encoded an enzyme that plays a crucial role in the metabolism of retinol (vitamin A).