LRAT and colonic neoplasm: Furthermore, studies have suggested its potential involvement in the development and progression of various cancers, including gastric and thyroid cancer.[30,31] DHRS9, a member of the SDR family, is thought to be a promising target for preventing the formation of malignancies like colon cancer since it has been reported in multiple studies to play a critical role in the development and progression of various tumors.[32–34] Lecithin retinol acyltransferase (LRAT) served as the primary enzyme responsible for facilitating the esterification of vitamin A (all-trans retinol).