NOTCH3 and cognitive disorder: In a multicenter retrospective study, carriers of the mutations p.Arg607Cys or p.Arg544Cys in exon 11 had a significantly lower frequency of migraine with aura, were more susceptible to cognitive disorders, and had an older onset age.[14] In our case, gene sequencing indicated that 3 Chinese family members had a pathogenic missense mutation of c.128G>A (p.Cys43Tyr) in exon 2 of NOTCH3.