NOTCH3 and cerebral arteriopathy with subcortical infarcts and leukoencephalopathy: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare monogenic inherited disease caused by a mutation in the notch homolog protein 3 (NOTCH3) gene on chromosome 19p13.12 region; it is the most common hereditary stroke disease.[1,2] More than 400 NOTCH3 mutations have been reported globally.[3] Generally, the clinical manifestations of CADASIL are observed in adulthood (age: 40–50 years).