The induction, activation and level improvement of CD4+ T cells have a significant implication on the prognosis of sepsis.[32,33] Dendritic cells or monocytes stimulate the activation of CD4+ T cells, which in turn release immunomodulatory cytokines and orchestrate the function of cytotoxic CD8+ T cells.[8] Through flow cytometry, Zheng et al[34] assessed T lymphocyte subgroups and the influence of vitamin D on children suffering from sepsis. Here, CD8A is linked to Sepsis.