Interestingly, the lymphocyte and T cell count could rapidly recover within 48 hours in surviving critically ill patients,[35] consistent with findings from large multicenter studies.[36] The downregulation in CD4+ and CD8+ immunity may underscore the sepsis occurrence and mortality.[37] Given this, 120 sepsis patients were segregated into 3 groups: sepsis, severe sepsis and septic shock, with 40 individuals in each group, for a clinical observation study. The gene discussed is CD4; the disease is Shock.