KLK3 and posterior cortical atrophy: Research suggests that as a PCa screening test, PSA has limited specificity, leading to overdiagnosis and subsequent overtreatment.[13] Another meta-analysis found that PSA screening increased the diagnosis rate of PCa but did not reduce overall mortality or disease-specific mortality.[14] To improve specificity and reduce unnecessary biopsy procedures, exploration of new serum markers for early detection of PCa is still needed.