TP53 and glioblastoma: Having been reported in the literature, the crucial role of the p53 signaling pathway in GBM is highlighted, with the inhibition of this pathway by SNRPG being shown to enhance the sensitivity of GBM cells to TMZ, thereby aiding in overcoming chemotherapy resistance.[21] These pathways may play a role in the development or progression of GBM, and targeting them could offer potential therapeutic strategies for inhibiting GBM progression.