Cell cycle has been shown to play a decisive role in the occurrence and development of GBM.[35,36] In both breast cancer (BRCA) and GBM, key roles were played in cell cycle regulation, with lncRNAs TUG1, LINC01355, CASC9, and FOXC2-AS1 impacting cell proliferation and apoptosis in breast cancer, while cell cycle arrest leaded to reduced proliferation and subsequent cell death in GBM, revealing specific differences in cell cycle regulation between BRCA and GBM.[37,38]. This evidence concerns the gene TUG1 and breast carcinoma.