Then the risk score of each GBM patient in the training set was calculated as the expression of ANAPC4 * −0.082 + expression of CCNB1 * 0.015 + expression of CDC25B * −0.013 + expression of CHEK1 * 0.008 + expression of PLK1 * 0.115 + expression of SMAD3 * 0.048 + expression of YWHAG * 0.699 + expression of YWHAZ * 0.60. Here, SMAD3 is linked to glioblastoma.