For instance, inhibition of JAK or STAT phosphorylation decreases antiapoptotic protein levels, leading to apoptosis in GBM cells.[27] Studies have found that curcumin inhibits STAT activation and downstream target genes involved in cell proliferation, migration, and invasion, reducing GBM cell migration, invasion, and proliferation.[28] These results suggested that prognostic cell cycle-related genes may regulate the development and progression of GBM via cell proliferation. This evidence concerns the gene SOAT1 and glioblastoma.