Coronary artery disease, heart failure, and chronic kidney disease can exacerbate chronic hypoxia and reduced blood flow in the gastrointestinal mucosa, leading to an elevation in angiopoietin (Ang) Ang-2 levels.[11,12] A decreased Ang-1/Ang-2 ratio can induce abnormal angiogenesis and reduce vascular stability. This evidence concerns the gene ANG and heart failure.