Our results shown that a high LRRS was associated with high tumor purity and low immune and stromal scores, and the fraction of memory B cells, CD8+ T cells in low LRRS group were significant higher than these in high LRRS group, which are major immune effector cells.[45] Our findings suggest low antitumor immunity in patients with a high lactate metabolism risk. The gene discussed is CD8A; the disease is neoplasm.