PI3K-Akt signaling pathway and apoptosis signaling pathway play a pivotal role in various pathological stages of asthma airway inflammation, airway hyperreactivity, and airway remodeling.[41–43] Human cytomegalovirus infection signal pathways and Epstein-Barr virus infection signal pathways have been demonstrated that they play a key role in immunological modulation.[44,45]. This evidence concerns the gene AKT1 and Epstein-Barr virus infection.