IL-17 signaling pathway contributes to the occurrence and development of inflammatory immune diseases.[38] The level of transcription of IL-17 in serum and airway of asthma patients is markedly elevated.[39] TNF signaling pathway can regulate cell death and inflammatory response, which is closely related to the pathogenesis of allergic asthma.[40] PI3K-Akt signaling pathway is involved in the regulation of cell growth, differentiation, survival and apoptosis. Here, TNF is linked to asthma.