In addition, BUB3 is also abnormally expressed in many human malignancy, such as prostate cancer, glioma tumors, colorectal cancer, breast cancer, hepatocellular carcinoma, adrenocortical carcinoma, and gastric cancer.[39] HOTAIR is a prevalent long noncoding RNA in human malignancies influencing 17 different tumor types such as breast, cervical, esophageal squamous cell carcinoma, and colorectal cancers. This evidence concerns the gene BUB3 and Familial prostate cancer.