BUB3 and neoplasm: Silva et al noted levels were elevated in oral squamous cell carcinoma patients compared to normal cells, and suppressing Bub3 or Spindly proved toxic to these cancer cells while also enhancing their sensitivity to cisplatin treatment.[37] Kang et al[38] evaluated the effect of BUB3 on survival outcomes of surgically resected nonsmall cell lung cancer patients and found that Bub3 mRNA was highly expressed in tumor tissues, and the overall survival of patients with BUB3 rs7897156C > T was worse.