BUB3 and esophageal squamous cell carcinoma: In addition, BUB3 is also abnormally expressed in many human malignancy, such as prostate cancer, glioma tumors, colorectal cancer, breast cancer, hepatocellular carcinoma, adrenocortical carcinoma, and gastric cancer.[39] HOTAIR is a prevalent long noncoding RNA in human malignancies influencing 17 different tumor types such as breast, cervical, esophageal squamous cell carcinoma, and colorectal cancers.