Patients with CD3G mutations exhibit a distinct genetic signature in their T-cell repertoire, which may be a contributing factor to the higher incidence of autoimmunity observed in these individuals.[26] According to Wang et al, CD3G is a potential prognostic and immunotherapeutic biomarker in patients with cervical cancer.[27]CD3G is a hub gene significantly associated with good prognosis in head and neck squamous cell carcinoma.[28]. The gene discussed is CD3G; the disease is head and neck squamous cell carcinoma.