The protein encoded by EOMES, a transcription factor essential for embryonic development of the mesoderm and central nervous system in vertebrates, may be required for the differentiation of effector CD8 + T cells involved in defense against viral infection.[29] Dielmann et al found that higher EOMES mRNA expression was an independent prognostic factor for OS and PFS in patients with sorafenib.[30]EOMES is a key transcription factor involved in regulating the development and function of CD4 T cells, promoting their differentiation into various effector cell types, such as Th1 and Th2.[31]. This evidence concerns the gene CD4 and viral infectious disease.