we identified CD8 + T lymphocyte-related biomarkers of RCC using bioinformatics technology, including apolipoprotein B mRNA editing catalytic polypeptide 3G (APOBEC3G), CD3 gamma (CD3G), eomesodermin (EOMES), protein tyrosine phosphatase, non-receptor type 7 (PTPN7), signal regulatory protein gamma (SIRPγ), Fas ligand (FASLG) and T-cell immunoreceptor with Ig and ITIM domains (TIGIT). The gene discussed is TIGIT; the disease is renal cell carcinoma.