NBEAL2 and autoimmune disease: Moreover, these clinical phenotypes were summarized in a large cohort of 47 GPS patients, including reduced leukocyte counts, increased presence of autoimmune disease and positive autoantibodies, the multiple types of blood cells are deficient in granule proteins.[2,3] Moreover, John et al[5] found that NBEAL2 is required for neutrophil and NK cell function and pathogen defense in NBEAL2-deficient mice, neutrophils showed a severe reduction in granule contents across all granule subsets, and the NBEAL2-deficient NK cells were dysfunctional and showed reduced degranulation.