NBEAL2 and hemorrhagic disease: Moreover, novel clinical phenotypes were also observed which the immunity defects beyond the bleeding disorders in GPS, and NBEAL2 mutation was also required for neutrophil and NK cell function.[5] Thus, neutrophils and NK cells were both examined by the flow cytometry to examine the degranulation in this family, but no significant results were observed in these family members(Fig. 4A and B), demonstrating that these 2 NBEAL2 mutations were not associated with the degranulation of neutrophil or NK cells.