CAMKK2 and osteoarthritis: One of its published papers, “CAMKK2 is upregulated in primary human osteoarthritis and its inhibition protects against chondrocyte apoptosis,” discusses how calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) is upregulated in OA cartilage, correlating with increased levels of pro-apoptotic and catabolic proteins.