Furthermore, E2F2 expression was markedly reduced in hepatic macrophages of the MASH group compared to the simple steatosis group (Figure 1P,Q), whereas no significant differences were observed in other cell types (Figure S1H, Supporting Information), including hepatocytes (Figure S1J, Supporting Information), HSCs (Figure S1K, Supporting Information), and ductular cells (Figure S1L, Supporting Information). This evidence concerns the gene E2F2 and steatosis.