A vital prognostic factor for liver‐related outcomes and overall mortality in individuals with metabolic MASH is advanced liver fibrosis.[48] Studies have indicated a strong association between the activation of HSCs and TGF‐β1 in the fibrogenesis process associated with the progression of MASH.[49] Nonetheless, the precise mechanisms by which macrophages influence fibrogenesis in MASH remain unclear. This evidence concerns the gene TGFB1 and metabolic dysfunction-associated steatohepatitis.