In order to investigate the translational possibility of Nrf2/E2F2 in macrophage and cause there is no E2F2 specific agonist, we established HFD‐induced mouse MASH model with Nrf2 specific agonists (RTA 408 and CDDO) or PBS treatment. The gene discussed is E2F2; the disease is metabolic dysfunction-associated steatohepatitis.