After local injection, the CP@Gel released CP and autocatalytically generated ROS for caspase‐3 activation, and the systematically administered DAC was able to inhibit the methylation of Gsdme to elevate the GSDME protein level, eventually resulting in robust pyroptosis and an anti‐tumor immune response that inhibited TNBC proliferation and postoperative recurrence. This evidence concerns the gene GSDME and neoplasm.