However, while previous meta-analyses of RCT investigating vitamin D supplementation on inflammatory biomarkers have reported inconsistent findings(43–45), some have shown significant effects for at least one biomarker of inflammation, including IL-6, TNF-α or CRP, in patients with heart failure(43), type 2 diabetes(45) and abnormal glucose homeostasis(44). The gene discussed is IL6; the disease is type 2 diabetes mellitus.