No significant difference between treatment groups was found in three RCT measuring IL concentrations (IL-6 or IL-10) following 25 μg, 50 μg or 100 μg daily in African American adults(23), average weekly doses (mean ± sd) of 2133 μg ± 400 in Latino and African American adults with pre-diabetes and hypovitaminosis D(24) or monthly doses of 3000 μg or 300 μg in Asian Indian obese children and adolescents(25). The gene discussed is IL10; the disease is diabetes mellitus.