EHMT2 overexpression (P < 0.01, Figure S2C and S2D) increased EHMT2 and H3K9me2 enrichment on the SH3BGRL promoter (P < 0.01, Figure 4C), and SH3BGRL expression was downregulated in AML cell lines, further diminished in resistant lines, but upregulated with ALKBH5 silencing (P < 0.01, Figure 4D and 4E). This evidence concerns the gene ALKBH5 and acute myeloid leukemia.