An extensive prospective study that examined the relationship between Lp(a) and PAD in the Copenhagen cohort found that people whose Lp(a) levels were in the 99th percentile or higher had a considerably elevated risk of PAD, as well as a higher incidence of major adverse limb events (MALE) and lower limb amputations compared to those whose levels were in the 50th percentile or lower [134]. Here, LPA is linked to peripheral arterial disease.