LPA and atrial fibrillation: On the other hand, higher Lp(a) levels were associated with a higher risk of developing AF, according to an epidemiologic and genetic analysis of the UK Biobank carried out by Pedrum Mohammadi-Shemirani et al. [114], they hypothesized that Lp(a) influences myocardial tissue beyond the aortic valve and coronary arteries, and this finding was replicated in two Mendelian randomization analyses that utilized independent data [115, 116].