Lipopolysaccharide promotes aerobic glycolysis in pulmonary fibroblasts by activating the PI3K-Akt-mTOR/6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) signaling pathway, which promotes collagen synthesis in pulmonary fibroblasts and contributes to pulmonary fibrosis [18]. The gene discussed is PFKFB3; the disease is pulmonary fibrosis.