Ginsenoside also promotes PD-L1 expression, reduces interleukin-12 (IL-12) secretion, and blocks CD8 + T cell and hepatic stellate cell activation through the PI3K-Akt-FoxO1 pathway in liver fibrosis, thereby alleviating liver injury and fibrogenesis [58]. Here, AKT1 is linked to Hepatic fibrosis.