ZBP1 and Sepsis: IP results demonstrated an increase in ZBP1 polyubiquitination levels upon LPS stimulation, while the addition of eCIRP significantly reduced the LPS-induced polyubiquitination of ZBP1 by Ub-TRIM32 (Fig. 9f), underscoring eCIRP’s inhibitory effect on ZBP1 ubiquitination during sepsis.