Conversely, sodium oxamate (OXA), a specific inhibitor of lactate dehydrogenase suppressing lactate production, significantly attenuated the sepsis-induced increases in plasma lactate (Fig. 1a) and exosomal CIRP (Fig. 1b), while also ameliorating lung injury in septic mice (Fig. 1c, d). The gene discussed is CIRBP; the disease is Sepsis.