AMH and primary ovarian failure: The classic definition of premature ovarian failure (POF) is the absence of menstruation for 4–6 consecutive months in women under 40 years of age, accompanied by elevated follicle-stimulating hormone (FSH) and decreased estradiol and anti-Müllerian hormone (AMH) levels1, and its incidence varies in different regions, with a number of studies reporting an incidence between 1%2 and 5.5%3, which is not only the main cause of ovarian infertility4 but also the clinical symptoms, such as endocrine disorders and perimenopausal syndrome, caused by this condition seriously affect women’s health5.