The classic definition of premature ovarian failure (POF) is the absence of menstruation for 4–6 consecutive months in women under 40 years of age, accompanied by elevated follicle-stimulating hormone (FSH) and decreased estradiol and anti-Müllerian hormone (AMH) levels1, and its incidence varies in different regions, with a number of studies reporting an incidence between 1%2 and 5.5%3, which is not only the main cause of ovarian infertility4 but also the clinical symptoms, such as endocrine disorders and perimenopausal syndrome, caused by this condition seriously affect women’s health5. The gene discussed is AMH; the disease is endocrine system disorder.