Furthermore, by collecting fresh normal and tumorous surgical samples from the same patient with CRC (Supplementary Table II), we found ZBP1 expression is significantly lower or absent in tumor compared to their matched noncancerous colonic tissues, while the expression of Casp-6, RIPK3 and MLKL were generally comparable in both normal and tumorous tissues (Fig. 7b). The gene discussed is ZBP1; the disease is colorectal carcinoma.