Furthermore, by collecting fresh normal and tumorous surgical samples from the same patient with CRC (Supplementary Table II), we found ZBP1 expression is significantly lower or absent in tumor compared to their matched noncancerous colonic tissues, while the expression of Casp-6, RIPK3 and MLKL were generally comparable in both normal and tumorous tissues (Fig. 7b). This evidence concerns the gene CASP6 and colorectal carcinoma.