A recent study reported the stabilization of lactate through the SUMOylation of two residues on anaphase-promoting complex.64 SUMOylation targeting mitophagy by regulating the conjugation of MFN1/2 SERCA2a, HIF1α, and PINK1 has also been reported in cardiovascular diseases.65 In this study, we first reported the mechanism of SUMOylation in OA and found that MFN1/2 were not only modified by ubiquitination but also SUMOylated by SUMO2/3, which indicated that MFN1/2 were also degraded by SUMOylation and thus enhanced the level of mitophagy in OA. The gene discussed is MFN1; the disease is cardiovascular disorder.