HDAC9 and neoplasm: Depsipeptide treatment induces an increase in global acetylation levels and apoptosis.109,110 Similarly, panobinostat, a broad-spectrum HDAC inhibitor, trigger cell differentiation and inhibits tumor growth in ecMRT models.111 Interestingly, while the broad-range HDAC inhibitor vorinostat did not affect tumor growth in an ecMRT xenograft model when administered in combination with irradiation, the treatment showed greater efficacy against rhabdoid tumors.112