In the future, we will continue to expand the sample size to explore the relationship between MTHFR C677T and A1298C polymorphism and the development of T2DM in Dali area of Yunnan Province, which has certain referencevalue for the early screening of high-risk groups in this area, and provides a new ideafor the prevention of T2DM patients. Here, MTHFR is linked to type 2 diabetes mellitus.