MK was identified as a promoting differentiation factor of cancer at embryo stage (Sorrelle, Dominguez & Brekken, 2017), but the overexpressed MDK in the stemness B cells 1 may be suppress the proliferation of hematopoietic stem cells through binding the NCL receptor (Wu et al., 2020; Fig. 6B). The gene discussed is MDK; the disease is cancer.