Such as the HHD-ALL cases with more than chromosomes had the most common t (12; 21) (ETV6/RUNX1) rearrangement, occurring in 20–25% of patients and representing nearly half of the encountered chromosomal anomalies in B-ALL and associating with a favorable prognosis (Moorman et al., 2010). Here, RUNX1 is linked to acute lymphoblastic leukemia.