KDM5B encode a jmjc domain-containing histone demethylase that was up-regulated in various cancer to represses the transcriptional function as an oncogene (Li et al., 2020), Wang et al. (2024), revealed that upregulated KDM5B can enhance tumor malignancy, including the drug resistance and cancer cells stemness. The gene discussed is KDM5B; the disease is cancer.