The overexpressed HLA-F in the B cells 1 can bind the receptor of CD8A in cytotoxic NK/T cells promoting the killer role (Fig. 7A), the chemokines CCL can bind the CCR5 receptor to induce T lymphocytes migration for anti-infection (Sharapova et al., 2018; Fig. 7B), ICOS can induce the activation, proliferation and survival of T cells through binding CD28 (Blotta et al., 1996; Fig. 7C), the TNFSF14 can promote the proliferation and effector of T cells (Tamada et al., 2000; Fig. 7D), these results supported that the stemness B cells 1 promote the activity of cytotoxic NK/T cells. Here, ICOS is linked to infection.