Hu et al. (2019) reported that lipasin levels of the exercise group decreased significantly compared to pre-exercise levels in their study in which they utilized aerobic exercise 5 days a week and 30 min a day for 6 months in individuals with type 2 diabetes and obesity. Moreover, Karaman, Arslan & Gürsu (2022) examined the serum lipasin levels of four different groups (G1: control group; G2: metabolic syndrome control group; G3: metabolic syndrome + aerobic exercise; G4: metabolic syndrome + anaerobic exercise) in their study in which they applied six-week exercises on rats. This evidence concerns the gene ANGPTL8 and obesity due to melanocortin 4 receptor deficiency.