Similarly, there was an evident increase of IL‐33 in advanced DN patients (urinary albumin‐to‐creatinine ratio (ACR) > 300 mg/g, glomerular filtration rate (eGFR) < 90 mL/min/1.73 m2), but not early DN (ACR between 30 and 300 mg/g, eGFR > 90 mL/min/1.73 m2) (Figure 1H). This evidence concerns the gene ALB and liver dysplastic nodule.