PLN and cardiomyopathy: Therefore, apart from sarcomeric HCM and Z‐disc HCM, genes encoding Ca2+‐handling or Ca2+‐regulatory proteins (PLN, CALR3, CALM3,141 Junctophilin 2 [JPH2],142, 143 CASQ2, RYR2) have been proposed as potential causal genes for HCM,144 further indicating the heterogeneity in the etiology and pathogenesis of cardiomyopathy.