observed that administering rapamycin at a dose of 2.24 mg/kgxd or implementing a 40% caloric restriction for a duration of 9 weeks enhanced Akt–mTORC1 signaling, partially reinstated autophagic flux, and successfully rescued cardiomyopathy in Mybpc3‐targeted KI mice. The gene discussed is MYBPC3; the disease is cardiomyopathy.