NR3C2 and heart failure: Although “new quadruple” drugs for heart failure such as ACEI/ARB/ARNI (Benazepril, Valsartan, Sacubitril/valsartan, etc.), beta blockers (Metoprolol, Bisoprolol), aldosterone receptor antagonists (Spironolactone), SGLT2 inhibitors (Engliflozin, Dagliflozin, etc.)have brought hope to the treatment of patients with heart failure (7), many patients still experience poor control every year requiring repeated hospitalization or even leading to death.