STAT3 and colonic neoplasm: In addition, quercetin could increase also the expression of CB1R in a mouse model of induced colon cancer, inhibiting the mediators of proliferation (STAT3, p-STAT3) and inducing the markers of apoptosis [Bcl-2-associated X protein (Bax)/B cell lymphoma-2 (Bcl-2)], thereby leading to the suppression of colon carcinogenesis [22] (Table 1).