The flavonol quercetin (Figure 1) was recently demonstrated to be able to significantly upregulate the CB1R expression in human colon adenocarcinoma cells, leading to the inhibition of downstream survival signaling of phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) and induction of the proapoptotic pathway of c-Jun N-terminal kinase (JNK)/JUN. This evidence concerns the gene AKT1 and colon adenocarcinoma.