Overexpression of CXCR4 has been indeed detected in various human malignancies, including colon cancer, pancreatic cancer, breast cancer, ovarian cancer, and prostate cancer, presenting as an important pro-invasive factor that is associated with increased metastasis, resistance to conventional therapies, recurrence, and poor prognosis in patients [3, 4]. The gene discussed is CXCR4; the disease is malignant colon neoplasm.