CXCR4 and colonic neoplasm: Furthermore, the hops-derived prenylated chalcone xanthohumol (Figure 1) could repress the expression of CXCR4 in various cancer cell types, including human breast cancer cells MDA-MB-231 and colon cancer cells SW620, occurring at the transcriptional level and leading to the abrogation of CXCL12-induced invasion [3] (Table 1).