PKD1 in myeloid linage cells contributes to the increased expression of TNFα, IFNγ, IL-1β, IL-12, IL-17A, IL-23, CXCL9, CXCL10, CXCL11, and CCL20, resulting in CXCR3+CCR6+ nonconventional Th1 cell accumulation and activation in the lung, alveolitis, and granuloma formation following repeated exposures to S. rectivirgula. Here, CXCR3 is linked to hypersensitivity pneumonitis.