(39) found that Berbamine could up-regulate the expression levels of caspase-3, caspase-9 and Bax by inhibiting the Wnt/β-catenin signaling pathway, inhibiting the proliferation activity of Human ovarian cancer SKOV-3 cells line(SKOV-3) and Human ovarian cancer ES-2 cells line(ES-2) cells. The gene discussed is CASP3; the disease is ovarian carcinoma.