In lung adenocarcinoma, IFITM1 upregulates the expression of IL-1α/1β, VEGFA, and IL-6 by activating the STING-TBK1-IRF3 pathway, promoting monocyte recruitment, and M2 macrophage polarization, resulting in immune suppression (80). The gene discussed is STING1; the disease is lung adenocarcinoma.