Additionally, immune checkpoint molecules (e.g., CCR4, CD27, CD274, CD68, CTLA4, PDCD1, and PDCD1LG2) were significantly upregulated in the AERShigh group (Figure 8B, all p < 0.01), suggesting potential impairment of the anti-tumor immune response. The gene discussed is PDCD1LG2; the disease is neoplasm.