EGFR and hepatocellular carcinoma: Through the leave-one-out cross-validation (LOOCV) framework, 167 machine learning procedures were constructed to predict the prognosis of HCC patients based on the Anoikis-ErbB related genes, and the LASSO + RSF model was selected for the optimal Anoikis-ErbB Related Signature (AERS), achieved the highest C-index, and demonstrated superior predictive power over 72 published predicting models.