ATG16L1 and colitis: Atg16l1HM mice, an engineered mouse strain with low expression of ATG16L1, infected with a persistent strain of murine norovirus (MNV), demonstrated aberrant secretion of Paneth cell granules strongly resembled those observed in individuals carrying the ATG16L1 T300A variant and higher susceptibility to DSS-induced colitis compared to WT mice (14).