PPARGC1A and neoplasm: C1QBP is a mitochondrial protein, the deletion of which increases mitochondrial fission through Adenosine 5’-monophosphate-activated protein kinase (AMPK)/PGC-1α signaling and inhibits mitochondrial biogenesis, further impairing mitochondrial plasticity and metabolism; this affects the number, depletion, and memory phenotype of tumor-infiltrating lymphocytes (TILs) (30).