PPARGC1A and neoplasm: Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha (PGC-1α), a crucial component of the mitochondrial biogenesis signaling cascade, not only promotes central memory T cell (Tcm) formation but also improves the structural and metabolic adaptability of CD8+ T cell mitochondria in tumor microenvironment (TME).