EPAS1 and metabolic dysfunction-associated steatohepatitis: Moreover, studies in transgenic mice carrying hepatocyte-specific deletion of HIF2α and analysis performed on MAFLD/MASH patients have shown that HIF2α activation is a key feature of both experimental and human MASH, where HIF-2α levels were strictly associated, in a positive loop manner, with hepatocyte production of SerpinB3, a factor able to deeply affect lipid metabolism (93, 94).