SERPINB3 and hepatocellular carcinoma: SerpinB3 (also known as SCCA1, squamous cell carcinoma antigen) is a member of the family of serine protease inhibitors (Serpins) which is almost undetectable in normal hepatocytes, while it is upregulated in chronic liver disease (86) and over-expressed in hepatocellular carcinoma (79, 87).