Other mechanisms include damage to the vascular endothelium due to oxidative stress (Munzel et al., 2017), altered coagulation status due to fluctuations in the expression levels of coagulation factors (Kim et al., 2010), and imbalance in the levels of insulin and leptin secretion due to endocrine disorders (Cassidy et al., 2016). This evidence concerns the gene INS and endocrine system disorder.